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280 W River Park Drive Suite 110 Provo, UT

Why POTS Treatment Needs a Neurological Lens (vs. Cardio‑Only)

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Today’s healthcare system largely treats postural orthostatic tachycardia syndrome (POTS) as a cardiovascular problem. We treat it as an autonomic nervous system regulation problem in the brain and brainstem that creates downstream cardio symptoms.

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The autonomic nervous system (ANS) controls heart rate, blood pressure, and blood‑gas responses to posture changes.

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The vestibular organs and cranial nerves feed those centers; miscalibration can lead to oversized heart rate and blood pressure response when standing.

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Breathing mechanics and CO₂/O₂ balance strongly affect cerebral blood flow and tissue oxygen delivery.

How Our Program Is Different: We're Treating the Problems With a Different Tool Kit

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We're not asking your body to adapt to dysfunction—we're retraining the dysfunction itself

Traditional approaches try to build tolerance around a broken system. Compression socks, salt loading, and slow cardio reconditioning help you cope with dysregulation, but they don't fix the autonomic nervous system that's causing it.


Our approach targets the brainstem and autonomic centers that are causing the exaggerated heart rate and blood pressure responses. We're recalibrating the thermostat, not just adjusting to a room that's always too hot.

pots-programs

We use tools that most POTS programs don't even consider

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Therapeutic CO₂ use - Most providers see CO₂ as waste. We use it to improve oxygen delivery and teach your blood vessels to respond appropriately.

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Vestibular recalibration - Your inner ear sensors tell your brain about position changes. When these are miscalibrated, your nervous system overreacts to standing. We directly retrain these sensors.

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Cranial nerve activation - Strategic use of taste, smell, and sensory inputs to influence the brainstem centers that control heart rate and breathing in real-time.

interval-recovery

Our interval-recovery method teaches your nervous system to switch gears


Standard reconditioning keeps you in moderate zones for long periods. Our Neuro-Cardio Training uses brief rounds working through all heart rate zones, including higher and lower, along with precise recovery. This teaches your sympathetic (gas pedal) and parasympathetic (brake pedal) systems to work together again—the core problem in POTS.


You're not just building stamina; you're retraining the autonomic reflexes themselves.

concussion patients

We have a specific origin story: concussion patients with POTS

This protocol wasn't invented for POTS—it was discovered while treating patients with post-concussion syndrome (PCS). We noticed our PCS patients with POTS symptoms were recovering their autonomic function through neurological rehabilitation. We then refined and formalized what was working into a dedicated POTS program.


This means our approach emerged from actual patient outcomes, not theory.

supervised recalibration

Four days of intensive, supervised recalibration vs. months of trial-and-error at home

Most programs send you home with general exercises and hope. We provide 4 days of hands-on, real-time adjustment of your treatment based on how your nervous system responds. Then you leave with a personalized protocol that's already been tested and refined on your specific dysregulation pattern.

The bottom line:

If you've tried cardiovascular reconditioning, medication management, and lifestyle modifications without lasting improvement, it's likely because those approaches aren't addressing the neurological regulation problem. We're treating a different layer of the problem—and that's why patients who've "tried everything" often see results they haven't experienced before.

Standard POTS Treatment Approach vs. Cognitive FX

Most Healthcare Providers logo
Primary Focus Cardiovascular deconditioning — aims to gradually rebuild exercise tolerance through low-to-moderate steady-state cardio. Neurological retraining — targets the autonomic nervous system (ANS) to restore proper regulation of heart rate, blood pressure, and breathing.
Underlying Theory POTS is a heart and blood vessel issue. POTS is a form of dysautonomia — an ANS and regulation issue that manifests as cardiovascular symptoms.
Treatment Tools Salt tablets, high water intake, compression garments, medications, and gradual recumbent-to-upright cardio. Multi-modal neurological retraining: Neuro Cardio Training, vestibular recalibration, cranial nerve activation, breathing mechanics, and carbon dioxide therapy.
Cardio Method Long-duration, low-intensity cardio focused on conditioning. Proprietary Neuro-Cardio Training method that recalibrates and teaches the sympathetic and parasympathetic nervous systems to work together again and respond appropriately to exercise.
Vestibular Work Rarely included or generalized balance work. Targeted vestibular recalibration (especially saccule/vertical orientation) to reduce orthostatic overreaction.
Breathing Approach Basic relaxation or endurance breathing. Retrains nasal/diaphragmatic mechanics and CO₂/O₂ balance to directly influence ANS function and blood flow.
Cranial Nerve
Integration
Not addressed. Activates smell/taste/trigeminal inputs to influence brainstem centers that regulate HR and breathing.
CO₂ & Oxygen Use Viewed as waste vs. intake gas; not targeted. Uses CO₂ therapeutically (CarboHaler inhalation pre-cardio, CO₂ suit recovery) to improve oxygen delivery and vasodilation.
Role of Medication Central—used to manage HR, BP, and volume (beta blockers, fludrocortisone, midodrine, etc.). Secondary—may supplement care but not required; goal is self-regulation without lifelong medication dependence.
Program Goal Manage symptoms and maintain functionality. Retrain autonomic control and improve long-term quality of life.
Duration of Program Ongoing home program; indefinite. 4-day intensive (evaluation + 3 treatment days) plus structured home continuation plan.
Outcome Focus POTS symptom stabilization. System regulation and sustainable improvement in exercise tolerance and daily function.
Primary Focus

Most Healthcare
Providers

Cardiovascular deconditioning — aims to gradually rebuild exercise tolerance through low-to-moderate steady-state cardio.

CFX

Neurological retraining — targets the autonomic nervous system (ANS) to restore proper regulation of heart rate, blood pressure, and breathing.

Underlying Theory

Most Healthcare
Providers

POTS is a heart and blood vessel issue.

CFX

POTS is a form of dysautonomia — an ANS and regulation issue that manifests as cardiovascular symptoms.

Treatment Tools

Most Healthcare
Providers

Salt tablets, high water intake, compression garments, medications, and gradual recumbent-to-upright cardio.

CFX

Multi-modal neurological retraining: Neuro Cardio Training, vestibular recalibration, cranial nerve activation, breathing mechanics, and carbon dioxide therapy.

Cardio Method

Most Healthcare
Providers

Long-duration, low-intensity cardio focused on conditioning.

CFX

Proprietary Neuro-Cardio Training method that recalibrates and teaches the sympathetic and parasympathetic nervous systems to work together again and respond appropriately to exercise.

Vestibular Work

Most Healthcare
Providers

Rarely included or generalized balance work.

CFX

Targeted vestibular recalibration (especially saccule/vertical orientation) to reduce orthostatic overreaction.

Breathing Approach

Most Healthcare
Providers

Basic relaxation or endurance breathing.

CFX

Retrains nasal/diaphragmatic mechanics and CO₂/O₂ balance to directly influence ANS function and blood flow.

Cranial Nerve Integration

Most Healthcare
Providers

Not addressed.

CFX

Activates smell/taste/trigeminal inputs to influence brainstem centers that regulate HR and breathing.

CO₂ & Oxygen Use

Most Healthcare
Providers

Viewed as waste vs. intake gas; not targeted.

CFX

Uses CO₂ therapeutically (CarboHaler inhalation pre-cardio, CO₂ suit recovery) to improve oxygen delivery and vasodilation.

Role of Medication

Most Healthcare
Providers

Central—used to manage HR, BP, and volume (beta blockers, fludrocortisone, midodrine, etc.).

CFX

Secondary—may supplement care but not required; goal is self-regulation without lifelong medication dependence.

Program Goal

Most Healthcare
Providers

Manage symptoms and maintain functionality.

CFX

Retrain autonomic control and improve long-term quality of life.

Duration of Program

Most Healthcare
Providers

Ongoing home program; indefinite.

CFX

4-day intensive (evaluation + 3 treatment days) plus structured home continuation plan.

Outcome Focus

Most Healthcare
Providers

POTS symptom stabilization.

CFX

System regulation and sustainable improvement in exercise tolerance and daily function.

How Our POTS Evaluation & Treatment Works

comprehensive
Day 1

Comprehensive POTS Evaluation

  • Functional testing of orthostatic response, vestibular function, cranial‑nerve inputs, and breathing mechanics.


  • Education about POTS, how neuro training helps, and how we’ll customize your treatment plan.

multi-modal
Days 2–4

Multi-Modal Treatment (~4–5 hours/day)

  • Neuro-Cardio training to teach the ANS to switch gears.


  • Vestibular recalibration exercises that improve vertical‑change sensing and reduce orthostatic overreactions.


  • Breathing mechanics work to influence ANS function and blood flow.


  • Cranial-nerve stacking to steer autonomic tone.


  • End‑of‑day CO₂-based recovery suit for relaxation and tissue perfusion.


  • Planned rest blocks to protect tolerance.


Home program: You leave with daily drills and a repeatable interval‑recovery framework.

Patient Reviews

How ONE-D TMS is different from rTMS and SAINT TMS

1. How long does ONE-D TMS take compared to the different treatment options?

Conventional repetitive TMS (rTMS) is a proven treatment, but it is often logistically burdensome, requiring dozens of clinic visits over four to six weeks. The ONE-D protocol is a breakthrough designed to eliminate this barrier by condensing the entire course of therapy into a single, 9.5-hour day (20 sessions delivered every 30 minutes). This accelerated regimen makes effective treatment feasible for patients who live far from a clinic, have mobility issues, or cannot take weeks off work for daily appointments.  SNT TMS is basically the ONE-D TMS protocol that is repeated for 5 days instead of one.

2. How does ONE-D differ from other accelerated protocols like SAINT TMS?
  • Duration: ONE-D is a single-day (9.5-hour) treatment, whereas SAINT (Stanford Accelerated Intelligent Neuromodulation Therapy) is typically a 5-day course.

  • Targeting: SAINT uses personalized targeting via functional MRI (fMRI) to locate the exact stimulation site. ONE-D uses a validated, scalp-based heuristic target for the left posterior DLPFC, making the procedure more accessible and faster to set up.

  • Response Onset: A key finding of the ONE-D study was a delayed therapeutic response, with symptom improvement steadily increasing and reaching a plateau between weeks 4 and 6 post-treatment. This contrasts with the SAINT protocol, which reported a much more rapid response, with remission achieved in an average of 2.6 days.

  • SAINT, via a Magnus Medical machine, is an FDA-approved treatment.  ONE-D uses FDA-approved iTBS but is still considered off-label.
3. What is "Neuroplastogen Enhancement," and is it unique to ONE-D?

The "Neuroplastogen-Enhanced" element is central to the ONE-D protocol's ability to achieve high results in a single day. ONE-D is optimized by administering a single pre-treatment dose of two off-label medications, D-cycloserine (DCS) and lisdexamfetamine, about an hour before starting TMS. These agents are included to enhance neuroplasticity—the brain's ability to create new connections—which may increase the treatment's effect and durability. Conventional rTMS and SAINT TMS typically do not include this type of pharmacological augmentation.

4. How effective is the ONE-D single-day treatment compared to the multi-week options?

The retrospective case series found that the ONE-D regimen achieved unexpectedly high and sustained efficacy despite its brevity and non-personalized targeting. At Week 6 post-treatment, patients achieved:

  • Response Rates: Approximately 88% across depression (HDRS-17, PHQ-9) and anxiety (GAD-7) scales.

  • Remission Rates: Over 70% on the main depression scales (HDRS-17, BDI-II).

  • The main question that remains is how durable the recovery is and how often follow-up care is needed.  
5. Is the ONE-D protocol safe, and are the results long-lasting?

The ONE-D regimen was found to be safe and well-tolerated, with every patient successfully completing the full 20 sessions on schedule and no serious adverse events reported. The most common side effect was transient scalp discomfort and headache during or in the week following treatment, which is common with TMS. The high response and remission rates were largely maintained out to 12 weeks of follow-up, suggesting the benefit is durable. The study's authors note that a single-day treatment, if replicated under formal randomized conditions, could substantially increase the overall value of TMS as a practical treatment option.

6. Is ONE-D TMS covered by insurance?

Given that the protocol is so new, most insurance plans do not yet cover the treatment.  We currently offer it on a cash basis or can try to arrange a single case treatment agreement with your existing insurance.  The single case agreement is most effective if you have already met your deductible, given the $2500 cost of the scan plus treatment is generally below most deductibles.