Your Symptoms Are Real. Your Brain Scans Prove It.
You've been told it's anxiety. That your tests are normal. That you just need more rest. We see what others miss: measurable brain dysfunction that responds to targeted treatment.
The infection cleared months ago, but you're still not yourself. The brain fog that makes simple tasks feel impossible. The crushing fatigue that sleep doesn't fix. The frustrating moment when you can't find the right word.
Memory problems
Brain fog
Slowed thinking
Difficulty concentrating
Crushing fatigue
Why Standard Long COVID Treatments Aren't Working
Despite billions in research funding, clinical trials keep failing. The treatments that should work, don't.
The Largest Long COVID Trial Just Confirmed It
The RECOVER-NEURO trial, published in JAMA Neurology in January 2025, tested three evidence-based rehabilitation approaches across 328 patients at 22 sites.[1]
None of them demonstrated meaningful improvement over placebo.
Computerized brain training failed. Cognitive behavioral rehabilitation failed. Transcranial direct current stimulation failed. And this isn't an isolated finding. Trials of antivirals and anti-inflammatories have produced similarly disappointing results.[2]
What Hasn't Worked for Long COVID
Antivirals (Paxlovid, Ensitrelvir)
Mixed results in trials. The virus is already gone in most Long COVID patients.
Extended Antibiotics (for Lyme)
Eight randomized controlled trials show "no effect" on quality of life, cognition, or fatigue.[3]
Generic Cognitive Rehabilitation
Without imaging guidance, these programs can't target your specific dysfunction patterns.
What Long COVID Does to Your Brain
Research from Johns Hopkins, the UK Biobank study, and imaging centers worldwide has documented measurable brain changes that persist long after viral clearance.[4]
Neurovascular Coupling Dysfunction
Blood vessels fail to deliver oxygen where neurons need it. Brain regions become starved of resources, forcing inefficient compensation patterns that cause fatigue and brain fog.
Neuroinflammation
PET and fMRI studies show activated microglia and reactive astrocytes across multiple brain regions, persisting long after viral clearance.[5]
Autonomic Dysregulation
The balance between "fight or flight" and "rest and digest" systems becomes disrupted, causing palpitations, temperature issues, dizziness, and POTS.
Structural Brain Changes
The landmark Douaud et al. study in Nature documented reduced grey matter thickness and tissue damage in frontal and memory areas.[6]
Wondering If We Can Help Your Long COVID Symptoms?
Our free consultation helps determine if your symptoms match the patterns we've successfully treated in thousands of patients.
It might seem unusual. But peer-reviewed research shows Long COVID and post-concussion syndrome cause remarkably similar brain dysfunction.
Symptom Prevalence: Long COVID vs. Post-Concussion Syndrome
Peer-reviewed data shows substantial overlap across all major cognitive symptoms
Symptom
Post-Concussion
Long COVID
Memory Problems
21-33%
27-28%
Brain Fog
39-47%
32%
Slowed Processing
23-31%
42-54%
Difficulty Concentrating
21-33%
22-24%
Fatigue
32-47%
32-43%
The overlap isn't a coincidence. Both conditions involve the same underlying brain dysfunction: disrupted neurovascular coupling, neuroinflammation, and autonomic dysregulation.
A 2024 direct comparison study found no statistically significant differences in psychological functioning between the two groups.[7]
Sources: Premraj et al., J Neurol Sci 2022; Elboraay et al., BMC Neurology 2025; van der Vlegel et al., J Clin Med 2021; Ceban et al., Brain Behav Immun 2022[8-11]
Our Long COVID Treatment Approach: See the Problem, Then Fix It
Unlike generic rehabilitation programs, we use functional brain imaging to identify your specific dysfunction patterns and design treatment that targets them directly.
1
Before Treatment
Functional NeuroCognitive Imaging (fNCI)
Our specialized fMRI protocol measures brain function across 56 regions while you perform cognitive tasks. The scan produces over 7,000 images revealing exactly which areas are underperforming and which are overcompensating.
2
Treatment Week
Personalized EPIC Treatment
One intensive week of multidisciplinary therapy targeting your specific dysfunction patterns. Neuromuscular, cognitive, vision, vestibular, sensorimotor, autonomic regulation, and psychotherapy are sequenced to maximize neuroplasticity.
3
After Treatment
Measured Results
A follow-up fNCI scan objectively documents changes in brain function. You'll see the before-and-after comparison yourself, with clear evidence of your progress.
What Makes Our Long COVID Treatment Different
The RECOVER-NEURO trial used generic, non-personalized rehabilitation. Participants received the same treatments regardless of their specific brain dysfunction patterns.
Our approach is fundamentally different:
fMRI-guided: Treatment targets your specific dysfunction, not generic protocols
Multidisciplinary: Multiple specialties working together, not isolated interventions
Intensive: One focused week, not months of weekly appointments
Measured: Pre and post imaging documents actual brain changes
Proven: Independently validated by University of Groningen researchers[12]
Long COVID Treatment Results
The majority of patients who complete our program report meaningful improvement in their symptoms.
77%
showed significant symptom reduction in peer-reviewed research
1,000+
patients treated annually at our clinic
10+
years treating brain dysfunction
56
brain regions measured in our imaging
Our outcomes have been independently validated by researchers at the University of Groningen, representing rare third-party verification in the neurorehabilitation field.
Post-Treatment Lyme Disease: The Same Brain Problem
If you're struggling with persistent symptoms after Lyme disease treatment, you're facing a remarkably similar challenge to Long COVID patients.
A 2022 Johns Hopkins study found that 14% of Lyme patients who were diagnosed early and treated promptly still developed lasting symptoms.[13]
Why antibiotics can't fix PTLD: Northwestern University research (2025) shows bacterial cell wall fragments accumulate in tissues and continue triggering inflammation long after live bacteria are eliminated. More antibiotics can't clear debris that isn't alive.[14]
Other Post-Infectious Conditions We Treat
Long COVID and Lyme disease are examples of a pattern that has repeated throughout medical history. Various infections can trigger lasting brain dysfunction.
We also work with patients experiencing lasting cognitive symptoms from:
Post-viral fatigue syndromes including Epstein-Barr/mononucleosis
Encephalitis and post-encephalitic syndromes
Other bacterial infections that have affected brain function
If an infection has left you with persistent cognitive symptoms and standard treatments haven't worked, our imaging-guided approach may help.
Is Long COVID Treatment Right for You?
We carefully screen all potential patients to ensure we only accept those we believe we can help. Not everyone is a candidate, and we'll be honest about whether our approach is likely to work for your situation.
You may be a good candidate if:
Cognitive dysfunction (brain fog, memory problems, difficulty concentrating) significantly impacts your daily life
Your symptoms developed following a viral or bacterial infection
You've been struggling with symptoms for more than three months
Standard treatments have failed to provide meaningful improvement
You can travel to our clinic in Provo, Utah for one week
Treatment is delivered over one intensive week at our clinic in Provo, Utah. This includes your initial fNCI scan, a full week of personalized therapy (typically 4-6 hours per day), and a follow-up scan to measure progress.
The RECOVER trial used generic, non-personalized interventions. Our approach uses functional brain imaging to identify your specific dysfunction patterns, then designs treatment that targets them directly. It's the difference between a one-size-fits-all program and precision medicine.
We can discuss pricing and financial options during your free consultation. Many patients have successfully used HSA/FSA funds for treatment, and we can provide detailed documentation for potential insurance reimbursement claims. At this time we don't bill insurance.
Yes. We have extensive experience treating patients with significant fatigue, including those with post-exertional malaise. Our team adjusts treatment intensity to your capacity, and we build in rest periods. Many patients find their fatigue improves during the treatment week itself.
You don't need a history of concussion. Peer-reviewed research shows Long COVID and post-concussion syndrome cause the same types of brain dysfunction: disrupted neurovascular coupling, neuroinflammation, and autonomic problems. A 2024 direct comparison study found no statistically significant differences between the two groups. The treatments we developed for concussion patients work because they target the dysfunction itself, not how it was caused.
Take the First Step Toward Long COVID Recovery
You've been dismissed, misunderstood, and told your symptoms might be psychological. We see the measurable brain dysfunction these conditions cause. We have the imaging to prove it. And we have a track record of helping patients reclaim their cognitive function and their lives.
1Knopman DS, et al. Evaluation of Interventions for Cognitive Symptoms in Long COVID: A Randomized Clinical Trial. JAMA Neurology. 2025;83(1):49-59. doi:10.1001/jamaneurol.2025.4415
2Beyond Antivirals: Alternative Therapies for Long COVID. PMC. 2024. Reviews metformin, LDN, dexamethasone, and other treatments. PMC11599064
3Dersch R, et al. Treatment of post-treatment Lyme disease symptoms: A systematic review. Eur J Neurol. 2024. doi:10.1111/ene.16293
4Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study. Lancet Reg Health West Pac. 2024. doi:10.1016/S2666-6065(24)00080-4
5Dadsena R, et al. Two-year impact of COVID-19: Longitudinal MRI brain changes. Psychiatry Clin Neurosci. 2025. doi:10.1111/pcn.13789
6Douaud G, et al. SARS-CoV-2 is associated with changes in brain structure in UK Biobank. Nature. 2022;604:697-707. doi:10.1038/s41586-022-04569-5
7Fry AK, et al. Emotional functioning in long COVID: Comparison to post-concussion syndrome using the Personality Assessment Inventory. Clin Neuropsychol. 2024;38(4):963-983. doi:10.1080/13854046.2023.2264546
8Premraj L, et al. Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: A meta-analysis. J Neurol Sci. 2022;434:120162. doi:10.1016/j.jns.2022.120162
9Elboraay MO, et al. Long-term neurological and cognitive impact of COVID-19: A systematic review and meta-analysis in over 4 million patients. BMC Neurology. 2025;25(1):250. doi:10.1186/s12883-025-04174-9
10van der Vlegel M, et al. Health care utilization and outcomes 1 year post injury. J Clin Med. 2021;10(4):806. doi:10.3390/jcm10040806
11Ceban F, et al. Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis. Brain Behav Immun. 2022;101:93-135. doi:10.1016/j.bbi.2021.12.020
12University of Groningen independent validation of Cognitive FX treatment outcomes. Available at: cognitivefxusa.com/our-research
14Jutras B, et al. Post-Treatment Lyme Disease Syndrome driven by remnants of infection. Northwestern University / Sci Transl Med. 2025.
Cognitive FX specializes in the diagnosis and treatment of brain dysfunction. We are not a replacement for your primary care physician or neurologist. If you are experiencing new or severe symptoms, please seek appropriate medical care.
