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Post-Concussion Syndrome & Medications for Mental Health

Image of Dr. Alina Fong Ph. D.
Updated on 05 December, 2023
Medically Reviewed by

Dr. Jaycie Loewen

Post-Concussion Syndrome & Mental Health Problems Don’t confuse one with the other!

Concussions may be the hardest form of traumatic brain injury to treat due to the convoluted nature of long-term symptoms and how those symptoms can be misdiagnosed or even undiagnosed.  

15 to 20% of those injured with a mTBI develop symptoms meeting criteria for psychiatric disease including PTSD, anxiety, panic disorder, OCD, and depression. Recent studies have also found a connection between increased risk of suicidality and head injuries.

Medications are often prescribed by a multitude of different clinicians to treat these types of symptoms, but the first concern is always whether or not the medications are appropriate for the patient.  

This problem becomes even more concerning as we see more patients who have been prescribed with several seizure medications, sleep aids, and psychiatric drugs. Often the side effects of these medications can mimic or even exacerbate the concussion symptoms we are trying to resolve.  

Thus starts a complicated Symptom-Medication-Exacerbation Cycle (SME Cycle). The more you continue the cycle the more symptoms increase or continue and medications get perscribed. 


Here is a table of common medications used for a concussion, along with their common side effects, that can influence the SME cycle:  

Drug Condition Being Treated  Side Effects 
Lamictal Seizures Insomnia, drowsiness, fatigue, dizziness, anxiety, pain, irritability, suicidal ideation, abnormal dreams, abnormality in thinking, agitation, amnesia, depression, emotional lability, hypoesthesia, migraine, confusion

Headaches, Depression, Fatigue, Insomnia

Sedation, impaired memory, delirium, hallucinations, convulsions, coma, cardiotoxicity



Agitation, fatigue, dizziness


Depression and PTSD

Insomnia, headache, dizziness, fatigue


Depression, Anxiety, PTSD, Panic and Social Anxiety

Drowsiness, insomnia


Depression and PTSD

Insomnia, headache, dizziness, fatigue, SIADH


PTSD and Depression

Elevated blood pressure, stimulant, agitation, neuromuscular activity decline


Mood Disorder and PTSD

Gyencomastia, dyskinesia, sedation, hyoptension


Mood Stabilizer

Agranulocytosis, diplopia, ataxia

If you are currently taking any of these and noticing that you aren’t feeling better, the above cycle may explain why. It is critical to recognize that if you have had a concussion or traumatic brain injury, this fact can be contributing to the cause of your symptoms. Please be open to talking to your doctor about reducing the medications, if possible.  

Using medications to treat a concussion or the effects of a concussion may be helpful in the short-term to mask some symptoms, but may not be an effective long-term solution. Please inform yourself about these medications and their side effects. Your doctor is your advocate and trying to find you relief; however, he or she may not always be aware of the long-term effects of the medications psychologically and how these meds may actually be inhibiting your brain from healing.

One of our goals is to help our patients need as few medications as possible so that we can get to the core problem of the brain injury, thus helping the brain readjust and recover without the need for multiple medications.

The goal is always to restore brain function to its fullest potential. Each injury and each person will heal differently, which is why we take a targeted and individualized approach to get to the bottom of the symptoms.


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