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Is SAINT TMS Right for Me? What It Is & Factors to Consider

Image of Dr. Mark Allen, Ph.D.
Updated on 10 February, 2025
Medically Reviewed by

Dr. Diane Spangler, Ph.D.

Is SAINT TMS Right for Me? What It Is & Factors to Consider

If you suffer from major depression, obsessive-compulsive disorder (OCD), or other mental health conditions, transcranial magnetic stimulation (TMS) has been proven to help. You may want to explore whether TMS is the right treatment for you.

Are you a good candidate for TMS therapy? What factors should you consider when determining this?

In this article, we’ll discuss these factors, focusing on the latest and most effective TMS protocol: Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT-TMS), which is what we specialize in at our clinic.

Below, we cover:


What Is SAINT TMS? How Is It Different from Traditional TMS?


SAINT TMS, also called the SAINT protocol or SAINT i-TBS, is a new TMS method FDA-approved for treatment-resistant depression in 2022.

Several characteristics separate SAINT TMS from the original form of TMS (repetitive TMS or rTMS):

Difference #1: Use of Intermittent Theta-Burst Stimulation (iTBS)

In 2018, the FDA approved a new version of accelerated TMS called Intermittent Theta-Burst Stimulation (iTBS). This method uses theta waves, the neural frequencies that the hippocampus uses to connect to other brain regions, form new memories, and regulate certain sleep phases.

This method is safe and effective; many patients experience improvements shortly after starting treatment. It is delivered in three-minute sessions instead of the ~40-minute sessions of rTMS. In addition, patients have also noticed a decrease in suicidal ideation, suggesting that iTBS could be an option to treat patients at high risk of suicide rapidly.

Difference #2: Use of Functional MRI (fMRI)

In the standard rTMS and iTBS protocols, the location to apply the magnetic coil (which delivers the brain stimulation) is calculated based on triangulation between the patient’s nose, ears, and top of the head. Coil placement involves measuring the scalp 5cm along the parasagittal plane anterior to the activation hotspot in the motor cortex.

This method is easy to implement and requires no further equipment, but it doesn’t account for variations in head size and shape or differences in brain organization between patients. In addition, it relies heavily on how well technicians can find the right spot.

This can significantly impact the overall treatment results, as even missing it by a few millimeters can lower the treatment’s effectiveness.

A much more accurate way involves using functional MRI to determine exactly where the treatment target area is located in the brain. This method, developed by the team at Stanford University, is a defining characteristic of the SAINT protocol.

Difference #3: Use of Neuronavigation

The SAINT protocol uses a technology called “neuronavigation” to ensure that the magnetic coil is placed over the exact spot on the patient's head that the fMRI identified as the target area for each treatment session. This is in contrast to standard TMS in which the magnetic coil is placed manually by clinicians during each treatment session, leading to variability in coil placement from session to session.

Difference #4: A One-Week Treatment

In contrast to rTMS, which requires four to six weeks of treatment, with ~40-minute sessions five days per week, SAINT TMS offers a more efficient one-week treatment plan. Patients sit for 10 three-minute iTBS sessions daily for five days, making it much more convenient for people to complete amidst work, childcare, and other life commitments.

Effectiveness of SAINT TMS

SAINT TMS is now considered the gold standard treatment option for treatment-resistant depression.

In a double-blind randomized controlled clinical trial, about 85.7% of patients responded to the SAINT-iTBS treatment, meeting the criteria for reduced symptoms of depression, while around 78.6% achieved remission. All participants had treatment-resistant depression and had failed at least two other depression treatments. Encouragingly, one month after treatment, 60% of patients remained in remission.

The rapid achievement of high response and remission rates with SAINT-iTBS, combined with minimal side effects, makes it one of the most effective treatments available today.

A comparison of remission rates for rTMS/iTBS, electroconvulsive therapy (ECT), and SAINT-iTBS.

A comparison of remission rates for rTMS/iTBS, electroconvulsive therapy (ECT), and SAINT-iTBS.

The speed with which SAINT TMS can achieve high response and remission rates, combined with minimal side effects, makes it one of the best fact-acting treatments available today. With that said, there is limited data on the durability of these outcomes and how well they hold up over time. Some patients may see lasting remission or symptom reduction, while others may need follow-up treatments to maintain effectiveness.

As such, combining TMS with CBT, as we do at our clinic, is likely to produce the best results for patients. SAINT TMS can be used to get quick relief, while CBT can support long-term outcomes.

Factors That Indicate You’re a Good Candidate for SAINT TMS Therapy


You Have a Diagnosis of Major Depressive Disorder (MDD) or Treatment-Resistant Depression (TRD)


As mentioned above, SAINT TMS is currently FDA-approved as a new treatment option for major depressive disorder (MDD). In particular, if you have treatment-resistant depression (TRD) — i.e. multiple types of antidepressant medications or other depression treatments have failed to work for you — you’re likely a good candidate for SAINT TMS.

Antidepressant Medication Hasn’t Relieved Your Depression Symptoms


If antidepressant medications haven’t worked for you, you’re not alone. A 2022 reanalysis of the largest antidepressant study ever conducted found that traditional antidepressant medications only relieve symptoms in about one-third of patients who take them.

The study also showed that trying more than two different antidepressant medications brings little benefit for the patients, and less than 2% experienced success with a third or fourth medication.

If you fall into the two-thirds of people for whom antidepressant medications have no effect, this is a sign you may be a good fit for SAINT TMS (and TMS in general).

You’re Struggling with Side Effects from Your Antidepressant Medication


When taking antidepressant medication, many patients experience side effects, such as insomnia, headaches, nausea, blurred vision, irritability, anxiety, and irregular heartbeat. Most of these are mild and eventually go away, but others can be serious and have severe long-term consequences. For example, studies have shown that long-term use of antidepressant medication can increase your risk of certain illnesses, such as type 2 diabetes.

If you’re struggling to cope with side effects from your antidepressant medication, SAINT TMS is certainly a better option for you. This treatment is associated with only mild and short-lived side effects. Mild headaches and scalp discomfort are the most common side effects after a TMS session, but these symptoms often disappear after the initial sessions.

The most serious potential side effects of TMS are seizures, but these are very rare. Estimates suggest that less than three patients experience a seizure per 100,000 sessions. Even for patients who experience a seizure during treatment, it has no serious long-term consequences. There is no evidence that patients can experience multiple seizures during TMS sessions.

In less than 1% of cases, patients report unexpected emotional responses, including exaggerated mood swings and manic episodes. These occur especially in patients with bipolar disorder and taking antidepressant medication. In all cases, these psychiatric changes subsided shortly after treatment.

Traditional TMS (rTMS) Didn’t Work for You


If you’ve tried rTMS and failed to see any improvement, you may be reluctant to try TMS again. However, it is possible that your first TMS treatment failed because the method of placing the coil was imprecise or inconsistent.

As discussed above, SAINT TMS solves this issue. Using fMRI and neuronavigation ensures that the correct brain region is properly stimulated in nearly all patients, while simpler methods that rely on measurements taken over the patient’s scalp are successful in less than half.

Your Depression Is Seriously Affecting Your Daily Life


Depression can cause serious and debilitating symptoms that can affect daily life, including thinking about self-harm and suicide. Standard treatments such as antidepressant medication (which may actually increase suicidal thoughts) and talk therapy take weeks or months to begin working.

In contrast, TMS is a rapid and safe way to relieve depressive symptoms, including suicidal ideation. More than other types of TMS, SAINT has been shown to rapidly reduce the severity of suicidal ideation in just five days. There is some evidence that patients with suicidal ideation often have damage to areas of the brain that are involved in cognitive and emotional control, which happen to be the areas targeted during TMS sessions.

Your Life Commitments (Work, Childcare, etc.) Would Make Four to Six Weeks of Daily Treatment Difficult to Complete


Many people simply do not have the time to participate in 40-minute treatment sessions five days per week for four to six weeks. If this is the case for you, and you’re otherwise a good fit for TMS, SAINT TMS or another form of accelerated TMS is a good option for you.

You Have the Funds to Cover SAINT TMS


Currently, the original rTMS four to six-week protocol is the only form of TMS covered by insurance. However, each provider may have slightly different criteria for insurance coverage. For instance, some require patients to have failed four antidepressant medications and psychotherapy, while others are less strict, requiring failure of only two medications. Some insurers specify which types of medications — such as antipsychotics or different classes of antidepressant medications — must be tried first.

Additionally, coverage may vary based on the severity of symptoms, with some insurers covering moderate cases, while others limit coverage to severe conditions. Even after receiving insurance approval, patients should expect to pay a copay and/or deductible, which can vary depending on the specific insurance plan. For patients who require further financial assistance, payment plans, healthcare financing, or medical credit cards from companies like CareCredit may be an option.

If you want to opt for an accelerated or advanced protocol like SAINT TMS which gives you the best odds of achieving response or full remission, you’ll need to be able to pay out of pocket which can range from $6,000 to $15,000.

Factors That Indicate You’re Not a Good Fit for TMS


Most patients can safely undergo a TMS treatment, but some situations may rule out patients from TMS sessions. In most cases, it is a matter of assessing whether the increased risk outweighs the potential benefits. If these conditions apply to your medical history, our best advice is to discuss it with your healthcare provider.

You Have a Metal Implant In Your Head


TMS may not be possible for you if you have a metallic implant (or other objects) in the brain close to where the coil needs to be placed. This includes, for example, cochlear implants, Internal Pulse Generators, medication pumps, aneurysm clips or coils, stents, or even bullet fragments. Braces and dental fillings are acceptable for treatment.

Patients with these cannot undergo TMS because the magnetic fields could malfunction the implanted devices. Under normal circumstances, the heating produced during a TMS session is negligible and poses no risk to the patient. However, TMS can overheat metal objects and cause irreversible damage to the brain. Low-conductivity plastic and titanium implants are less prone to heating up.

You Have a History of Seizures


If you have a history of seizures, TMS may also not be right for you. Although rare, seizures can occur during TMS sessions and are more likely in patients with a previous history of seizures or suffering from neuropsychiatric diseases, including epilepsy, multiple sclerosis, traumatic brain injury, and Alzheimer’s disease, to name just a few.

The best way to minimize the risk of experiencing a seizure is to look at all factors that may increase your risk of seizures, such as prescription medication and history of seizures. In conjunction with your healthcare provider, you can weigh the pros and cons and decide whether TMS is suitable for you.

You’re Taking Certain Prescription Drugs


TMS may not be suitable for you if you’re already taking prescription drugs known to increase the risk of seizures. Although there is no evidence to suggest an increased risk of seizures beyond the risk already associated with TMS, if you’re currently on medication, it is important to discuss it with your healthcare professional before starting TMS. Your doctor may decide that you can undergo TMS sessions, but you may need to be followed more closely during your treatment.

You’re Younger Than 16 or Older Than 65 Years Old


At Cognitive FX, we are currently not treating patients younger than 16 and older than 65 for safety reasons. Preliminary studies show that TMS is likely safe for these patients, but further research is needed.

Is SAINT TMS Therapy Right for You?


Cognitive FX is one of less than ten clinics in the nation offering SAINT TMS, the current gold standard treatment for treatment-resistant depression. Our fMRI-guided treatment is completed in just one week. Patients receive ten TMS sessions daily for five days. Each session includes ten minutes of magnetic pulses and a 50-minute break between sessions.

To improve outcomes for our patients, we also include cognitive behavioral therapy (CBT) as a part of our treatment. When combined with the traditional method of TMS, CBT improved response and remission rates by ~8% and ~19%, respectively. Additionally, CBT is likely to produce sustained improvement over time once SAINT treatment has concluded.

If you are interested in receiving TMS therapy at Cognitive FX, click here to learn more.

Cited Research


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